OXIDATIVE STRESS AND ITS EFFECT ON PLATELET ACTIVITY
DOI:
https://doi.org/10.47390/ydif-y2026v2i2/n03Keywords:
oxidative stress, platelets, antioxidant, thrombocytosis, hemopoiesis, adhesion, degranulation.Abstract
Oxidative stress occurs as a result of an imbalance between the formation of reactive oxygen species (ROS) in cells and the antioxidant defense system. This condition has a significant impact on the function of blood formed elements, in particular platelets. Platelets play an important role in hemostasis, and their activation, aggregation and secretory functions are closely related to redox processes. At the same time, the activity of the antioxidant system is important in stabilizing the functional state of platelets. Endogenous antioxidant enzymes and exogenous antioxidant substances, including polyphenols, can reduce the negative effects of oxidative stress on platelets.
References
1. Varga-Szabó, D., Braun, A., & Nieswandt, B. (2009). Calcium signaling in platelets. Journal of Thrombosis and Haemostasis, 7(7), 1057-1066
2. Bergmeier, W., & Stefanini, L. (2009). Novel molecules in calcium signaling in platelets. Journal of Thrombosis and Haemostasis, 7, 187-190
3. G.Ramanathan, S.Gupta, I.Thielmann, I.Pleines Defective diacylglycerol –induced Ca²+ entry but normal agonist-induced activation responses in TRPC-6 deficient mouse platelets// Pud Med 2012
4. David Varga –Szabo ,Kalwant S Authi,Attila Braun. Store –Operated Ca ²+ enty in platelets occurs independently of transient receptor potential (TRP C₁ Journal of Thrombosis and Haemostasis, 8
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